Calico Creek is a rural locality in the Gympie Region, Queensland, Australia.

[1] Mary Valley Road (State Route 51) forms the north-eastern boundary.

Calico Creek, a tributary of the Mary River, rises in the south of the locality and flows through to the north.

Almost all of the southern boundary is the northern extent of Amamoor National Park.

[3] Calico Creek State School opened on 8 July 1936 and closed on 31 August 1970.