According to the APM Research Lab's Voter Profile Tools (featuring the U.S. Census Bureau's 2019 American Community Survey), the district contained about 491,000 potential voters (citizens, age 18+).

12% of residents 25 years and older have not graduated high school, while 26% hold a bachelor's degree or higher.

As of the 2020 redistricting, California's 25th congressional district is located in the Mojave Desert.

They are partitioned by Terwillinger Rd, Bailey Rd, Candelaria, Elder Creek Rd, Bonny Ln, Tule Peak Rd, Eastgate Trail, Goldrush Rd, Rule Valley Rd, Laura Ln, Dove Dr, Lago Grande, Barbara Trail, Valley Dr, Foolish Pleasure Rd, Highway 371, Gelding Way, Puckit Dr, Indian Rd, Wellman Rd, El Toro Rd, Burnt Valley Rd, Cahuilla Rd, Highway 74, Bull Canyon Rd, Santa Rosa-San Jacinto Mountains National Monument, Fred Waring Dr, Washington St, Highway 10, Davall Dr, Dinah Shore Dr, Plumley Rd, Gerald Ford Dr, E Ramon Rd, San Luis Rey Dr, San Joaquin Dr, Clubhouse View Dr, Mount San Jacinto State Park, Azalea Creek, Black Mountain Trail, Highway 243, North Fork San Jacinto River, Stetson Ave, Hemet St, Cornell St, Girard St, E Newport Rd, Domenigoni Parkway, Leon Rd, Grand Ave, State Highway 74, California Ave, W Devonshire Ave, Warren Rd, Ramona Expressway, San Jacinto River, Highway 79, Oak Valley Parkway, Champions Dr, Union St, Brookside Ave.

The 25th district takes in the cities of Coachella, Banning, Desert Hot Springs, Indio, San Jacinto, Hemet, Beaumont, Blythe, and Cathedral City as well as the census-designated places Valle Vista, East Hemet, Winchester, Cabazon, Whitewater, Desert Edge, Sky Valley, Thousand Palms, Indio Hills, Desert Palms, Bermuda Dunes, Vista Santa Rosa, Thermal, Oasis, Mecca, North Shore, Desert Center, Mesa Verde, and Ripley