The western segment runs from U.S. Route 101 near Klamath to Klamath Glen, while the eastern segment goes from Wautec Village to State Route 96 near Weitchpec.

The route begins at U.S. Route 101 near Klamath and after a discontinuity from Klamath Glen (near the McBeth Airport) to Johnsons via the Yurok Indian Reservation, resumes at the town of Wautec.

The highway continues through Pecwan before the curving road heads southeast and passes through Martins Ferry after several miles.

[4] Except where prefixed with a letter, postmiles were measured on the road as it was in 1964, based on the alignment that existed at the time, and do not necessarily reflect current mileage.

[1] Segments that remain unconstructed or have been relinquished to local control may be omitted.