The Harbor Freeway, which was constructed to interstate standards, opened in phases from the late 1950s to the 1970s and SR 11 was since transferred to that route.

It began in San Jose heading northeast from I-280 and US 101 and closely paralleling SR 17 (now I-880) until reaching Fremont.

[citation needed] The highway originally traveled along 10th Street in Los Angeles, but as Olympic Boulevard was built out to the west and east, it was aligned to that.

East of Los Angeles, the highway turned southeast along the Anaheim Telegraph Road, which it followed into Santa Fe Springs.

The portion east of Downtown Los Angeles was eventually deleted from the system as redundant to US 101 Byp.

When the freeway section between Foothill Boulevard and Interstate 215 was completed in 2007, the route was decommissioned and renumbered SR 210.

After being signed California 31, It was signed Temporary Interstate 15, and later, after being moved from Main Street in Corona, Hamner Avenue in Riverside County north of Corona, and Milliken Avenue in San Bernardino County to the Ontario Freeway.

The highway continued west on Centralia Road and then north along Pioneer Boulevard until reaching San Antonio Drive at Rosecrans Avenue.

Route 35 would wind through Rose Hills and Avocado Heights as Workman Mill Road and would then turn into Puente Avenue at Valley Boulevard where it would continue to its end at U.S. 99 at the border of Baldwin Park and West Covina.

The route was deleted in 1964 due to the replacement by Interstate 605 and SR 35 was redesignated along Skyline Boulevard in the San Francisco Bay Area.

The segment east of Interstate 5 (Santa Ana Freeway) was added to State Route 90.

It then headed north and intersected SR 216 in Woodlake and CR J27 amid farmland in the county.

The southern segment was deleted in 1994 (the same day the remainder of the current freeway opened) and the route was immediately transferred over to the cities of Cupertino and Saratoga.

State Route 157 was planned to run from I-805 near Ocean View Boulevard in San Diego to SR 125 near Sweetwater Reservoir, passing through the neighborhood of Paradise Hills.

[3] By 1974, plans called for constructing the freeway from Nogal Street across Imperial Avenue to end at SR 54.

[3] However, the community opposed the project; it would have passed through Balboa Park and would have gone through canyons, residential districts, and a golf course.

Between July 1, 1964, and the time it was turned back to local authorities, Route 206 ran from Highland Avenue, formerly State Route 30, in San Bernardino along North E Street, Kendall Drive, and Palm Avenue to the Barstow Freeway, Interstate 215, in Verdemont.

State Route 209 connected Point Loma with the interchange of I-5 and I-8 in San Diego.

The road as defined by the California State Legislature in the 1964 state highway renumbering would have begun at SR 86 2.5 miles (4.0 km) southwest of Brawley and ended 2 miles (3.2 km) west of Brawley.

State Route 252 was to connect I-5 to I-805, and provide almost direct access from I-805 to I-5, near the southern terminus of SR 15.

[25] The Comprehensive Planning Organization in 1974 proposed widening arterial streets nearby as an alternative, even though the construction would affect 240 buildings.

[28] By 1980, the California Transportation Commission had canceled plans to construct SR 252, due to the residential opposition.

[29] The city of San Diego opposed the idea of constructing an additional freeway, while the county supported it.

State Route 274 ran along Balboa Avenue, entirely within the city of San Diego.

The highway started at I-5 in Pacific Beach before continuing east into Kearny Mesa and intersecting I-805 and SR 163 before ending at I-15.

[43] State Route 285 was defined in 1970 as Route 70 on West Street in Portola northwesterly to the north city limits, then to Lake Davis via Humbug Canyon, and then easterly to Grizzly Reservoir via the south shore of the lake.

According to the Caltrans photolog, the old alignment for Route 285 essentially is exactly the same as existing West Street (in Portola) and Lake Davis Road northeast to Grizzly Road just northeast of the Big Grizzly Creek.

State Route 480 was a state highway in San Francisco consisting of the elevated double-decker Embarcadero Freeway (also known as the Embarcadero Skyway), the partly elevated Doyle Drive approach to the Golden Gate Bridge and the proposed and unbuilt section in between.

The unbuilt section from Doyle Drive to Van Ness Avenue was to have been called the Golden Gate Freeway and the Embarcadero Freeway as originally planned would have extended from Van Ness along the north side of Bay Street and then along the Embarcadero to the San Francisco-Oakland Bay Bridge.

The freeway was eventually demolished after the 1989 Loma Prieta earthquake, and Doyle Drive is now part of U.S. Route 101.