The highway intersects CR S2 and passes south of Coyote Wells before turning due east through the Yuha Desert.

The road passes over the New River and intersects CR S31 before entering the border city of Calexico, just opposite from Mexicali, the capital of the Mexican state of Baja California.

[3] The portion of SR 98 from SR 111 east to I-8 is designated as part of the Juan Bautista de Anza National Historic Trail auto tour route, promoted by the National Park Service.

[8] In 1935, a contract was awarded for "grading and surfacing" the portion from East Highline Canal to Midway Wells.

[16] Except where prefixed with a letter, postmiles were measured on the road as it was in 1964, based on the alignment that existed at the time, and do not necessarily reflect current mileage.