Calizzano (Ligurian: Carizan or Calissan) is a comune (municipality) in the Province of Savona in the Italian region Liguria, located about 70 kilometres (43 mi) southwest of Genoa and about 30 kilometres (19 mi) west of Savona.

Calizzano borders the following municipalities: Bagnasco, Bardineto, Bormida, Garessio, Magliolo, Massimino, Murialdo, Osiglia, Priola, and Rialto.

It is in the upper Bormida Valley.

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