It encompasses approximately 120 acres (0.49 km2), and the boundaries are Jefferson, Cherry, Madison (FL 100), and Temple Streets (US 301).

The historic district also serves as the City of Starke's primary restaurant and entertainment district, with a theatre, antique shops, restaurants, a history museum, and cultural center.

Located within the historic district is another location on the National Register of Historic Places, the Santa Fe College Andrews Center.

Call Street, which is part of Florida State Road 230, was named in honor of former Florida territorial governor, Richard K. Call.

This article about a property in Bradford County, Florida on the National Register of Historic Places is a stub.