Although originally described as a new species in 1915 and placed in the large genus Caloplaca in 1931, modern molecular phylogenetics suggests that its classification requires an update.

These results demonstrate that its genetic lineage is distinct from the Caloplaca (in the strict sense), a genus that is part of the subfamily Caloplacoideae.

[4] The secondary chemical makeup of Caloplaca cupulifera includes fragilin, a lichen product that contributes to the thallus's chrome-yellow colour and the soredia's bright yellow hue.

In the Galapagos, it is quite common, especially along the coast and in the dry zone, where it typically grows beneath shaded and sheltered rock overhangs.

[5] It is widely distributed in India, where it grows on both calcareous and non-calcareous rocks in moist and dry habitats of temperate to tropical areas.