Caluire-et-Cuire (French pronunciation: [kalɥiʁ e kɥiʁ] ⓘ; Arpitan: Caluéres-et-Cuéres) is a commune in the Metropolis of Lyon in the department of Rhône, Auvergne-Rhône-Alpes, eastern France.

It is the fifth-largest suburb of the city of Lyon, and lies 4 km north-by-east of Lyon.

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