Calyptogena magnifica is a species of giant white clam found clustered around hydrothermal vents at abyssal depths in the Pacific Ocean.

[2] Calyptogena magnifica was first described by Kenneth Boss and Ruth Turner of Harvard's Museum of Comparative Zoology, in 1980, following its discovery during research dives by the submersible vehicle DSV Alvin to the floor of the Pacific Ocean in 1977 and 1979.

The location of the thermal vent where it was found was approximately 200 miles (320 km) west of Punta Mita, Mexico at a depth of 2,645 metres (8,678 ft).

[2] Further deep water exploration shows that it is present at other thermal vents on the East Pacific Rise between 21°N and 22°S as well as in the Galapagos Rift.

[3] Calyptogena magnifica is assumed to burrow and it is thought the divided foot may be specially adapted for insertion into cracks in hard substrates or among mussels (Bathymodiolus thermophilus).

[4] Little is known of the reproduction and life cycle of Calyptogena magnifica but examination of specimens brought up from the deep showed numerous large oocytes with yolks in various stages of development among the visceral mass.