It is endemic to the Coast Ranges of northern and central California, where it grows on slopes and in woodlands, often on serpentine soils.

Calystegia collina is a rhizomatous perennial herb with densely hairy stems and foliage.

The stem lies flat and generally does not climb as many other morning glories do.

The small leaves are kidney-shaped or deeply lobed and are wavy or crinkly along the edges.

The inflorescence holds a single white flower 2 to 5 centimeters wide when fully open.