The station, informally known as Camagüey Central,[1] is owned by the state company Ferrocarriles de Cuba (FFCC) and is located in the Avenida Van Horne, in the middle of the city and just in front of the Hotel Plaza.

It is one of the most important stations of Cuba and, along with Havana Central, Santiago and Santa Clara, is a network's divisional headquarter.

[citation needed] Camagüey station has a large one-floor building in Spanish Colonial style.

2 km in south east, in the Garrido ward, it counts a larger shed with a motive power depot.

Other long-distance trains, principally departing/ending at Havana Central, link Camagüey to Holguín, Guantánamo, Bayamo, Matanzas, Ciego de Ávila, Las Tunas, Manzanillo and other cities.