[citation needed] It is the second most important stations of Cuba and, along with Havana Central, Camagüey and Santa Clara, is a network's divisional headquarter.

[3] The station, named after the Cuban politician Senén Casas Regueiro, was completely renewed and rebuilt in 1997.

[citation needed] The station lies in Los Pinos ward (reparto) and the line, counting a double track, is not electrified.

A junction, departing from the nearby village of El Cristo and arriving to La Maya (on the line to Guantánamo), was only partially built.

Other long-distance trains, principally departing/ending at Havana Central, link Santiago to Matanzas, Ciego de Ávila, Las Tunas and other cities.