This second building, a Colonial architecture structure of brick walls and red tiled roof, was again remodeled in 1925, for the one still standing, keeping the name of Marta Abreu.

Close to the main depot and just side the line to Camagüey, is located the Tren Blindado (armoured train) memorial of the Battle of Santa Clara.

Only the route to Esperanza (10 km, toward Havana) has a double track, due to the usage of the second rail for the line to Cienfuegos.

Other long-distance trains, principally departing/ending at Havana Central, link Santa Clara to Holguín, Guantánamo,[4] Bayamo, Manzanillo, Matanzas, Ciego de Ávila, Las Tunas and other cities.

[5] There are some inter-regional trains to Cienfuegos, Sancti Spíritus,[6] Morón[7] and Nuevitas, some regionals to Caibarién[8] and Sagua la Grande, and a suburban train connecting "Santa Clara" to the other city station (Santa Clara Universidad, 22°26′19″N 79°54′06″W / 22.43863°N 79.90157°W / 22.43863; -79.90157), serving the "Marta Abreu" University.