María Eugenia Vidal defeated Aníbal Fernández and became the governor of the populous Buenos Aires Province, ending 28 years of Peronist control.

[18] In June 2019, an extension of the Cambiemos alliance was made: it is renamed Together for Change, by adding to Federal Peronism led by Miguel Ángel Pichetto, who would share the presidential formula of space together with Mauricio Macri.

In the province of Buenos Aires, Governor María Eugenia Vidal sought re-election but was defeated by the candidate of the Frente de Todos, Axel Kicillof, who won 52% of the votes against 38% obtained by JxC.

[19] In the City of Buenos Aires, Horacio Rodríguez Larreta joins the Radical Civic Union and the Socialist Party to the district alliance and is reelected as Chief of Government with 56% of the votes in the first round.

[20][21][22] On 10 December 2019, the Centre-Left Alberto Fernández of the Justicialist Party was inaugurated President, after defeating the incumbent Mauricio Macri in the 2019 Argentine general election.

[23] On 14 November 2021, the center-left coalition of Argentina's ruling Peronist party, Frente de Todos (Front for Everyone), lost its majority in Congress for the first time in almost 40 years in midterm legislative elections.

[33] Macri said he would tear up Argentina's memorandum of understanding with Iran, seek Venezuela’s exclusion from the regional free trade association Mercosur and ease away from a fixed exchange rate with the dollar.

[34] He aligned the country with gradualist neoliberalism and re-opened Argentina to international markets by lifting currency controls, restructuring sovereign debt, and pressing free-market solutions.

[36] His presidency has been criticized for failing to materially reform the Argentine economy,[37][38] while receiving praise for leaving a legacy of anti-corruption,[39] and increasing Argentina's sovereign marketability.

[40][35] The members of Cambiemos were constituted to "promote economic development, the strengthening of democracy and the republican system, the independence of justice, the quality of education, social solidarity, and the personal happiness of the inhabitants of the Argentine Republic.

Mauricio Macri, Maria Eugenia Vidal, Horacio Rodríguez Larreta, Elisa Carrió, and ministers Marcos Peña, Rogelio Frigerio, Esteban Bullrich, etc., are anti-abortion; Martin Lousteau, Mario Negri, Luis Petcoff Naidenoff and ministers Sergio Rubinstein, Patricia Bullrich, Sergio Bergman, Juan José Aranguren, etc.

[57] Macri improved the relations with the United States[58] and from Mercosur achieved a free trade agreement with the European Union[59] and closer ties with the Pacific Alliance.

[60] Macri and his Foreign Minister Susana Malcorra endorsed Democrat Hillary Clinton in the 2016 US presidential election, which was won by Republican Donald Trump.

[61] Mauricio Macri said he wanted to start a "new kind of relationship" with the United Kingdom over the Falkland Islands as he tried to move his country towards a centrist position in world affairs.