The Edmundston campus of the Université de Moncton is built on an elevated area of the downtown core, near the Trans-Canada Highway.
The Pavillon sportif d'Edmundston is located on the campus grounds and includes a swimming pool, a climbing wall, different gymnasiums and more.
Prior to amalgamating with the Université de Moncton, the Edmundston campus was known as Collège Saint-Louis.
In 1949 the current campus was built, and its principal building was named the Simon-Larouche Pavillon after its first rector.
In 1949, the Religious Hospitallers of Saint Joseph founded a college for girls called Collège Maillet in nearby Saint-Basile which was affiliated with the Université Saint-Louis.