Taking place two years after the events of 428: Shibuya Scramble, Canaan centers on three women, their connections to one another, and an upcoming anti-terrorism summit in Shanghai, China.

The final girl is Maria Ōsawa, a returning character from the Shibuya incident, who came to Shanghai with her fellow reporter, Minoru Minorikawa.

Their subsequent encounters lead to armed interventions between Canaan and Alphard, along with the reveal of their deep and tragic past.

Minoru investigates a strange purple mark that he spotted from one of the assassins Canaan had killed recently, tying it back to the events in Shibuya.

Canaan later goes on a journey with Mino, Maria and several others to Western China where a new Ua virus was first used to find out about its origin and track down Alphard.

[6] A seventeen-second promo was subsequently streamed on the series' official website, featuring the dual DVD/CD release at Comiket.

Works,[9] directed by Masahiro Andō, who previously directed the Bones movie Sword of the Stranger,[10][11] and features series composition by Mari Okada, who previously wrote Vampire Knight and True Tears, and also features animation character designs by Kanami Sekiguchi and original music composed by Hikaru Nanase.

[18] A manga adaptation, illustrated by Akira Ishida, was serialized in Kadokawa Shoten's Comp Ace magazine between the August 2009[19][20] and March 2011 issues.

A poseable Figma Canaan figure was made by Miki Asai and released by Max Factory in November 2009.

[38] At the fourth annual Seiyu Awards, Miyuki Sawashiro was announced to be the Best Leading Actress for her role as Canaan.

He wrote about the "possessive love" that Liang Qi has for her sister (and the series antagonist), Alphard, the action scenes met with well put together scores, and noted some plot holes.