An ONA adaptation was produced by Trigger and directed by Akira Amemiya which aired from April to October 2015.

After the series grew in popularity, Enterbrain published the first Japanese-translated volume in print, Ninja Slayer: Neo-Saitama in Flames, in September 2012.

[citation needed] A manga adaptation with art by Yūki Yogo and scripted by Yoshiaki Tabata is serialized in Kadokawa Shoten's Comp Ace since June 27, 2013.

Another manga adaptation titled Ninja Slayer: Glamorous Killers (ニンジャスレイヤー グラマラス・キラーズ, Ninja Sureiyā: Guramarasu Kirāzu) with art by Ageha Saotome also began serialization from July 1, 2013, in Enterbrain's shōjo manga magazine B's-Log Comic.

In April 2014, Enterbrain announced that an anime adaptation of the novel was in production, later revealing that it was being produced by Trigger.