[1] On August 8, 2021, the Canadian Paralympic Committee announced the final team of 128 athletes (57 men and 71 women) competing in 128 sports.

[4] On August 21, 2021, judoka Priscilla Gagné was announced as Canada's flagbearer during the opening ceremony.

Karen Van Nest qualified by winning silver at the Pan American Championships in Monterrey, Mexico.

[7] Canada's track and field team of 16 athletes (nine men and seven women) was announced on July 30, 2021.

[9] Canada qualified in BC4 & Individual BC2 events, they include Danik Allard, Iulian Ciobanu, Marco Dispaltro and Alison Levine.

The mixed coxed four crews qualified by winning the gold medal at the 2021 Final Qualification Regatta in Varese, Italy.

[21] Qualification Legend: FA=Final A (medal); FB=Final B (non-medal); R=Repechage Canada qualified two shooters (one per gender) through bipartie slot allocations.

Tess Routliffe was scheduled to compete but withdrew from the swimming team following an injury that occurred at the World Para Swimming World Series finale in Berlin, Routliffe's teammate Danielle Kisser replaced her.

[25][26] The men's team qualified by winning the silver medal at the 2019 Parapan American Games in Lima, Peru.

Matteo Feriani The women's team qualified by winning the gold medal at the 2019 Parapan American Games in Lima, Peru.

[32] The Canadian team qualified for the games by winning the Final Qualification Tournament held in Richmond, British Columbia in March 2020.