The Society aimed to eliminate the "practice of cutting, burning or crushing any living man, bird or beast for experimental purposes".
[2][3] The Society was formed in July 1921 by Marguerite Mackay and Agnes Stanley in Toronto.
John B. Fraser, an anti-vaccinationist and germ theory denialist was the second president of the Society in the 1920s.
[3] In 1923, British anti-vivisectionist Walter Hadwen lectured at Forester's Hall, Toronto for the Society.
[6] Dora Kitto (1873–1949), Honorary Secretary founded a separate branch of the Society in Victoria, British Columbia.