The Canal Warehouse is a historic warehouse at the intersection of Main and Mulberry Streets in downtown Chillicothe, Ohio, United States.

Built in 1830,[1] along the Ohio and Erie Canal, this three-story brick building is an ornate gabled structure with large dormers set into both sides of the main roof.

These dormers served a purpose far different from decoration: their windows connect with first-floor doors to enable longshoremen easily to move goods into or out of the third floor.

[2] After it ceased to operate as a canalside warehouse, the building was converted into a clubhouse for the local post of the Veterans of Foreign Wars.

[1] Today, the warehouse has been recognized as a leading example of canal-related architecture; few warehouses built for the Ohio and Erie Canal survive in comparable condition.