Fifteen years later, on April 29, 2005, the center relocated to a newly constructed 195,845-square-foot (18,194 m²) hospital in Tulsa.

[8] On Dec. 29, 2008 CTCA opened Cancer Treatment Centers of America, Phoenix, with a 210,000-square-foot (19,500 m²) hospital serving patients primary from the west coast.

It also advertised in the Middle East, the Caribbean and Latin America, offering patients in these regions the opportunity to pursue treatment at one of its U.S. comprehensive cancer care and research centers.

[12] It was reported in December 2021 that CTCA would be acquired by Duarte, California-based City of Hope National Medical Center for $390 million[13] and the acquisition closed in early 2022.

Among other unsubstantiated claims, CTCA advertised that it was able to treat certain forms of cancer through specific procedures such as "whole body hyperthermia" and "brachytheraphy”.

[16] CTCA is also required to have proven, scientific evidence for all statements regarding the safety, success rates, endorsements, and benefits of its cancer treatments.

CTCA compared its outcomes with the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database.

"[23] The Truth in Advertising report noted that the FTC "rewrote the rules governing the use of testimonials, in 2009, to say that such disclaimers are not sufficient because consumers believe that theirs will be the atypical experience depicted in the ad.