Canine mastadenovirus A also causes disease in wolves, coyotes, and bears, and encephalitis in foxes.

[1] The virus is spread in the feces, urine, blood, saliva, and nasal discharge of infected dogs.

Corneal edema and signs of liver disease, such as jaundice, vomiting, and hepatic encephalopathy, may also occur.

[3] Diagnosis is made by recognizing the combination of symptoms and abnormal blood tests that occur in infectious canine hepatitis.

The disease can be confused with canine parvovirus because both will cause a low white blood cell count and bloody diarrhea in young, unvaccinated dogs.