[4][5] The genus contains the following species:[6] Viruses in Mastadenovirus are non-enveloped, with icosahedral geometries, and T=25 symmetry.

Subsequent binding of the penton protein to host integrin entry receptors mediates internalization into the host cell by clathrin-mediated endocytosis of the virus and fiber shedding.

Disruption of host endosomal membrane by lytic protein VI releases the viral capsid in the cytosol.

Import of the viral genome into host nucleus mediated by core protein VII.

Transcription of early genes (E genes) by host RNA pol II: these proteins optimize the cellular milieu for viral replication, and counteract a variety of antiviral defenses.

Virion maturation by the viral proteasehost receptors, which mediates clathrin-mediated endocytosis.

The virus exits the host cell by nuclear envelope breakdown, viroporins, and lysis.