Canthigaster supramacula, known as the West African sharpnose-puffer, is a species of marine fish in the family Tetraodontidae.

[2] It is named in reference to the conspicuous ocellus-like spot on its side, anterior to its dorsal fin's base.

Canthigaster supramacula can measure up to 3.9 centimetres (1.5 in), counting with no dorsal spines, possessing 10 dorsal soft rays and 9 anal soft rays.

It lacks dark stripes along the sides of the body like some of its cogenerate species, bearing two to four lines that extend from the caudal peduncle through the dorsal fin's base .

It is known from the Eastern Central Atlantic, first collected from off Côte d'Ivoire and Ghana.