After completing High School, Michele began to work in advertising, and won a scholarship for the Academy of Media and Journalism in Milan.

[3] Salvemini began his career as Mikimix, a b boy pop singer,[1] releasing the album La mia buona stella.

[4] He also anchored the broadcast Segnali di Fumo (Smoke Signals) together with Paola Maugeri [it] on the Video Music Italian channel.

In his second album, Caparezza talks about various problems distressing the Italian social reality through the ending of the old millennium as well as the beginning of the new one, also the condition of Southern Italy, with the characteristic cutting irony that made him be known.The single from this album "Fuori dal tunnel" ("Out of the Tunnel") enjoyed great success in Italy as a "summer hit"; however, the singer always opposed the song's use in clubs and on television because it was meant to denounce the de-individualization of entertainment.

Another song on Verità supposte is "Vengo dalla Luna" ("I Come From the Moon"), which tells the story of an alien (Caparezza) who comes to Earth and is astonished by humanity's intolerance of different races and cultures.

Salvemini reconnects to "Jodellavitanonhocapitouncazzo" (a pun with "jodel" of the phrase "Io della vita non ho capito un cazzo", "I don't understand shit about life"), the last song of Verità supposte in which the artist imagines his own death after becoming insane.

On 28 January 2011, he published the first single from the seventh album Il sogno eretico, entitled "Goodbye Malinconia", featuring Tony Hadley of Spandau Ballet.

Il sogno eretico, published on 1 March 2011 is a concept album that urges its listeners to reject tenets and dogma and to use critical thinking.

The songs allude to historic figures who were labeled heretics, including Galileo Galilei, Joan of Arc, Giordano Bruno and Girolamo Savonarola.

The album has been introduced by the videoclips of two songs: the nominal track "Prisoner 709" and the single "Ti fa stare bene" ("Makes You Feel Good"), published respectively on 7 and 15 September 2017.

Caparezza's band includes Rino Corrieri (drums), Gaetano Camporeale (keyboards), Giovanni Astorino (bass) and Alfredo Ferrero (guitar).

According to Jason Birchmeier, Caparezza's music features "an uncanny style of beats that defy much of the precedent established by [American hip hop]".

[19] Birchmeier says that Caparezza's beats "draw their sounds from everywhere" and "it's [his] experimental approach to beat-making, [and] mastery of the Italian dialect, [which makes his music] so stunning.

[1] Caparezza's live performances incorporate theatrical costumes, comedy sketches and monologues, projected videos, props, and actors.