Cape Girardeau Regional Airport (IATA: CGI, ICAO: KCGI, FAA LID: CGI) is a city owned public use airport in Scott County, Missouri, United States.

It is included in the National Plan of Integrated Airport Systems for 2017–2021, which categorized it as a commercial service - nonprimary airport based on passenger enplanements (the commercial service category requires at least 2,500 enplanements per year).

[2] Cape Girardeau Regional Airport covers an area of 557 acres (225 ha) at an elevation of 342 feet (104 m) above mean sea level.

[1] For the 12-month period ending September 30, 2018, the airport had 29,106 aircraft operations, an average of 80 per day: 91% general aviation, 5% scheduled commercial, 3% air taxi and 1% military.

It was operated under contract to Cape Institute of Aeronautics, Inc., with the civil instructors under the USAAF 73d Flying Training Detachment.