Cape Miseno (Italian: Capo Miseno, Latin: Misenum, Ancient Greek: Μισήνον) is the headland that marks the northwestern limit of the Gulf of Naples as well as the Bay of Pozzuoli in southern Italy.

The town of Miseno is located on the north side of the cape.

The cape is directly across from the island of Procida and is named for Misenus, a character in Virgil's Aeneid.

Historically, the cape was important to the Romans since it was a natural shelter for passage into the inner harbour of Portus Julius, the temporary home port for the Roman western imperial fleet from 33 BC.

Mythologically, important sections of the Aeneid play out in the Gulf of Naples: This is where Aeneas' comrade, Misenus, master of the sea-horn (the conch-shell) made "the waves ring" with his music and challenged the sea-god Triton to musical battle.