The series was part of a spate of attempts by major networks to develop prime time animated shows to compete with the success of Fox's The Simpsons, alongside CBS's Fish Police (also produced by Hanna-Barbera) and Family Dog.

A young mouse named Max is forced to flee his home on a farm in Nebraska after his family is killed by exterminators.

The group has to deal with the White House's resident cats, which are caricatures of then-President George H. W. Bush and Vice President Dan Quayle.

[10] In his review of the series, Variety critic Brian Lowry wrote that "at its best, the show seems to ape the work of film director Ralph Bakshi by using an animated setting to explore adult themes", and that "the bland central character and cartoonish elements [...] will likely be off-putting to many adults, who won't find the political satire biting enough to merit their continued attention.

[10] Capitol Critters had their own Burger King Kids Club toys in 1992, which featured Jammet, Max, Muggle, and a Presidential Cat sitting on or emerging from miniature Washington, D.C., monuments.