The film is based on the 2013 book The Good Nurse by Charles Graeber and is directed by Tim Travers Hawkins, who wrote the screenplay with Robin Ockleford.

Nearly all the hospitals where he worked harbored suspicions that he was endangering patients, but none of them informed Cullen's future employers of their concerns.

"[5] He was the subject of the 2013 true crime book The Good Nurse: A True Story of Medicine, Madness, and Murder written by journalist and author Charles Graeber,[6] and was featured in the 2022 film The Good Nurse by director Tobias Lindholm, starring Jessica Chastain and Eddie Redmayne.

There are interviews with family members of the victims, journalist and author Charles Graeber and audio from Cullen himself.

"[12] Film critic for Variety Owen Gleiberman suggests that both the documentary Capturing the Killer Nurse and the film The Good Nurse are "engineered to feel like a drama" and "show you that the Cullen saga may be the first case of a serial killer who was enabled by corporate malfeasance.