Emmy-nominated for her role as Dr. Faye Miller in Mad Men, she has played Karen Wheeler in the horror sci-fi series Stranger Things since its premiere in 2016.

[2][3][4] She attended Fiorello H. LaGuardia High School[5] and graduated from Columbia University with a double major in English and political science, which she completed in three years.

She starred in the final season of the NBC drama Third Watch (1999) as paramedic Grace Foster, and Ang Lee's feature film of Marvel Comics' Hulk in 2003 as the mother of the title character's alter ego, Bruce Banner.

She also appeared as Kelli, the wife of Christopher Moltisanti (Michael Imperioli), in the two-part final season of the HBO drama series The Sopranos, which aired in 2006 and 2007.

[8] Buono lives in New York City's Greenwich Village with her husband Peter Thum, founder of Ethos Water,[3] and their daughter.