Founded in Medellín in 1948 when La Voz de Antioquia station acquired the 50% of Emisoras Nuevo Mundo, based in Bogotá.

In 1945 Colombian Liberal Party politicians César García, Jorge Soto del Corral, Luis Uribe Piedrahita, Alberto Arango Tavera, Carlos Sanz Santamaría, José Gómez Pinzón, Alfonso López Pumarejo, and Alfonso López Michelsen created Sociedad Radiodifusión Interamericana, which would create the Emisora Nuevo Mundo in Bogotá.

Coltejer, a textile company which had invested in La Voz de Antioquia and Emisoras Nuevo Mundo, would own some shares until 1959.

[1] In 1956, Caracol owned and operated four stations: La Voz de Antioquia (Compañía Colombiana de Radiodifusión, Medellín, HJDM, currently Radio Reloj Medellín), La Voz del Río Cauca (Cali, currently Caracol Cali, HJED), Emisoras Nuevo Mundo and Radio Reloj.

On 12 August 2010 at 05:30 (10:30 UTC), a car bomb exploded outside the headquarters of the network, which did not interrupt its broadcast, despite having its building's tiles and windows shattered.