The groundbreaking for the school was performed on September 21, 1960 by then-bishop of Toledo, Bishop George J. Rehring.

The first principal was Monsignor Michael Walz, who initiated the "Stritch Family" concept.

They have adopted a service learning program, "Stewards of Stritch", moved from monthly to weekly Mass for all of its students, and helped the entire high school community focus toward the Eucharist as the source and summit of the faith and therefore, at the center of the school.

[3] In 2018, Cardinal Stritch was named a Top Workplace by the Toledo Blade and Energage.

On May 19, 2011, the school celebrated its 50-year anniversary with a mass presided by Bishop Leonard P. Blair.