During the George H. W. Bush administration, then-Labor Secretary Elizabeth Dole recruited her for the Department of Labor.

Dominguez served as Assistant Secretary for Employment Standards, Director of the Office of Federal Contract Compliance Programs (OFCCP) and Architect of the Labor Department's Glass Ceiling Initiative.

Dominguez had worked in OFCCP as an equal opportunity specialist prior to entering the private sector in 1981.

In addition to her government and corporate experience, Dominguez is also a founding member of an Adventist school, a Fellow of the Advanced Study Program in Public Management of the Massachusetts Institute of Technology and has served on the boards of the Leadership Foundation of the International Women's Forum and the Human Resources Planning Society.

She is currently Senior Vice President of Human Resources and Chief Talent and Diversity Officer of Loma Linda University Adventist Health Sciences Center.