The Colony's creation had been prompted by an influx of American prospectors to the Fraser Canyon Gold Rush three years earlier in 1858, which had its locus in the area from Lillooet to Yale.
The electorate of the Cariboo riding were among the most pro-Confederation in the colony, and this was in no small part because of the strong Canadian element in the local populace.
During the rush, the largest and most important town lay at the road's end at Barkerville, which had grown up around the most profitable and famous of the many Cariboo mining camps.
The wagon road's most important freight was the Gold Escort, which brought government bullion to Yale for shipment to the colonial treasury.
Cariboo Road by Alan Sullivan (published 1946), is a fictional historical novel about a family that travels from San Francisco to seek gold near Williams Creek.