[2] June graduated from the US Naval Academy in 1975 and earned his medical degree in from the Baylor College of Medicine in 1979.

June conducted postdoctoral research in transplantation biology with E. Donnall Thomas and John Hansen at the Fred Hutchinson Cancer Center in Seattle from 1983 to 1986.

After completing his training, he returned to Bethesda, where he founded the Immune Cell Biology Program at the Naval Medical Research Center and was head of the department of immunology from 1990 to 1995.

He was also a professor of medicine and of cell and molecular biology at the Uniformed Services University for the Health Sciences.

[4] June has been a pioneer in the field of immunotherapy, most widely known for the development of T-cell therapy for cancer.