After attending Kent School, he enrolled at Princeton University, from which he graduated in 1961 with a B.A.
[1][3] He began working at the National Institute of Mental Health in 1961 as a statistician, and continued to work there until 1987, eventually becoming director of their Division of Biometry and Applied Sciences.
He also began a mental health economics program at the NIMH and started their "Mental Health, United States" series, a regularly published report cataloging mental health statistics in the United States.
On September 28, 1989, he died of congestive heart failure at the Johns Hopkins Hospital in Baltimore, Maryland.
[2] In 1990, the American Public Health Association established the Carl Taube Award for Lifetime Contribution to the Field of Mental Health in honor of his work.