Boni worked as a singer for RAI, the Italian state radio and television network, since 1951.
She then won the Sanremo Music Festival 1953 with Flo Sandon's, singing "Viale d'autunno".
In 1955, Boni won the Festival di Napoli with the song "'E stelle 'e Napule", which she sang with her husband, Gino Latilla.
In 2007, she pulled out of the making of an album which was to be titled Aeroplani e angeli, with songs written by Alessandro Orlando Graziani.
[1] On 5 October 2008, Carla Boni participated in an event commemorating Pino Rucher (a RAI guitarist) twelve years after his death, which was sponsored by the Municipal Authorities of Manfredonia and by the Authorities of the Province of Foggia.