In the following decade, Sozzani served as editor-in-chief for all of Italian Vogue's special issues, collaborating with photographers and artists such as Sarah Moon, Herb Ritts, Bruce Weber, Paolo Roversi, Robert Mapplethorpe, William Wegman, and Deborah Turbeville.

The gallery primarily focused on photography and published exhibition catalogues and books on the work of Walter Albini, Pierre Cardin, Rudi Gernreich, Paco Rabanne, as well as numerous photographers.

She subsequently oversaw more than 250 exhibitions of photography and design, showcasing the works of artists such as Man Ray, Horst, Annie Leibovitz, Helmut Newton, David La Chapelle, Jean Prouvé, Marc Newson, Shiro Kuramata, Loretta Lux, and Robert Polidori.

The new 10 Corso Como Shanghai opened in a freestanding glass building, featuring photography, fashion, design, music, cuisine, a pastry café, and an outdoor terrace surrounded by plants.

In 2017, she established the Fondazione Sozzani, committed to advancing the quality and aesthetic depth of contemporary life by expanding knowledge of the history, execution, use, and presentation of both applied and fine arts.