Born in Sarzana, Province of La Spezia, he joined the Blackshirts in 1920, and co-signed the Fascist Intellectuals' Manifesto in 1925.
He fought in the Second Italo-Abyssinian War (as a lieutenant in the 84th Fanteria of the Division Gavinana in Italian East Africa), and rose to become inspector for the PNF, then (February 5, 1943) Minister of National Education and a Grand Council of Fascism member.
On July 25, Biggini voted against Dino Grandi's proposal for the removal of Mussolini, and stood by the Duce as the Social Republic was created with help from Nazi Germany.
Placing his seat in Padova, Biggini managed to avoid capture by the partisans in Dongo.
Protected by many fascists, he managed to avoid arrest, but fell ill and died under an assumed name in a Milan clinic.