Nordio served as deputy prosecutor of Venice until his retirement in 2017, dealing with economic crimes, corruption and medical liability.

[4] On 24 January 2022, Brothers of Italy's leader Giorgia Meloni proposed Nordio as her candidate in the 2022 Italian presidential election.

[7] On 29 January, Brothers of Italy voted him when all the other main parties proposed a re-election of incumbent president Sergio Mattarella.

[8][9][10] On the occasion of the 2022 referendum on justice, he promoted the reasons for the yes, joining, as one of its major exponents, the Committee for the yes.

[11] In the early political elections of 25 September 2022 he was a candidate for the Chamber of Deputies in the single-member constituency of Treviso for the center-right and as the leader of the Brothers of Italy in the multi-member Veneto.