Musumeci is serving as Minister for Civil Protection and Maritime Policies since 22 October 2022 in the government of Giorgia Meloni.

At the age of fifteen, Musumeci became a member of Giovane Italia, the youth organization of "Italian Social Movement", a neo-fascist and post-fascist political party in Italy.

After completing his studies in communication sciences, Musumeci began working as a banker at the UniCredit group a global banking and financial services company.

[5] Besides battling crime, Musumeci is grappling with pressing regional issues, including the effects of climate change, as Sicily has been experiencing major weather events that have impacted the coast in Palermo recently.

[6] Also, the Zafferana area in the vicinity of Mount Etna experienced a moderate earthquake on 26 December 2018 that left a number of people injured.

[8] Musumeci became a member of the Italian Senate in September 2022, and he serves as Minister for Civil Protection and Sea Policies since 22 October 2022 in the Meloni Cabinet.