Caserio served in a number of posts in the Córdoba provincial government under José Manuel de la Sota and Juan Schiaretti.

He began his political activism in the Peronist Left, and in 1978, he moved with his family to Valle Hermoso, a small town in the Punilla Department of Córdoba Province.

[6] In 1999, following the election of José Manuel de la Sota as governor of Córdoba, Caserio was appointed minister of public works.

[2] He was a supporter of the legalization of abortion in Argentina, voting in favour the two Voluntary Interruption of Pregnancy bill debated by the Argentine Congress in 2018 and 2020.

[11] Caserio stood for re-election in 2021 as the first candidate in the Frente de Todos list, alongside deputy Gabriela Estévez.