A member of Republican Proposal (PRO), he served as a National Senator for Buenos Aires Province from 2017 to 2021, and as Minister of Education from 2015 to 2017, during the presidency of Mauricio Macri.

After completing his bachelor's degree, Bullrich began his graduate studies in the United States at the Kellogg School of Management of Northwestern University in Evanston, Illinois.

After receiving his MBA Bullrich spent two months teaching mathematics to orphans in Nicaragua through the Padre Fabretto Foundation; he writes on his blog estebanbullrich.com that this experience "left a profound effect on me with regards to how a good education can help a child develop and achieve a more prosperous adult life" [quote translated from Spanish].

[2] This experience enabled him to meet American policy makers and study the US educational system with special attention on charter schools.

[3] In 2007, Bullrich took leave from the chamber of deputies to become interim Minister of Social Development of the Autonomous City of Buenos Aires.