[1] In 1999,[1] Lomelí became the director general of Lomedic, S.A. de C.V., which began supplying medicine to IMSS clinics in Jalisco.

[3] Beneficiaries complained about supply issues and other irregularities, prompting the state health secretary to change providers.

Additionally, at the time, Lomedic was placed by the United States Treasury Department on a list of 10 companies linked to drug trafficking activity;[3] he was removed from this list on 10 January 2012,[4] though a 2017 report returned him to the list and linked him to Raúl Flores Hernández's money laundering operation by way of a company called Servicios Educativos y de Negocios, S.A. de C.V.[5] In 2011, Lomelí founded another company, Laboratorios SOLFRAN, a Guadalajara-area maker of generic medicines.

[6] In February 2018, he resigned from the Chamber of Deputies in order to run for Governor of Jalisco as the Juntos Haremos Historia coalition candidate.

Lomelí finished second with 24.38 percent of the vote, behind winning candidate Enrique Alfaro Ramírez of Movimiento Ciudadano.