His first defense took place on June 24, 2006, when he defeated Joel Julio by unanimous decision in a welterweight title eliminator.

On February 9, 2008, Quintana challenged Paul Williams for the WBO welterweight championship, winning the fight by unanimous decision.

In the third round Quintana connected six consecutive punches to Cassiani's face, which made him collapse to the ring's canvas, the referee immediately stopped the fight.

Kolonivic was used as a late replacement and was scheduled to fight in the undercard of a card that included Jose Nieves vs. Alberto Ontiveros.

Quintana controlled the fight's tempo in the third and began the fourth round on the offensive scoring solid punches while trading combinations with his adversary, with one minute remaining in the round Quintana scored a knockdown and the fight was stopped seconds after when Suleyman didn't respond to his attack.

[10] On February 24, 2006, Quintana had his first professional championship fight, when he fought against Raul Bejerano of Argentina for the vacant World Boxing Organization's Latino welterweight title, in an event that took place in Ponce, Puerto Rico.

[5] On June 24, 2006, Quintana fought against Joel Julio of Colombia in a welterweight title eliminator sanctioned by the World Boxing Association.

[5] Quitana dominated the fight's tempo throughout the contest relying on his boxing skills while Julio tried to utilize his strength.

[11] On December 2, 2006, Quintana fought fellow undefeated Puerto Rican Cotto, who moved up in weight from Jr. Welterweight.

In the fifth round Cotto had control of the fight's tempo, and connected several combinations to the body, scoring a knockdown while switching between the orthodox and southpaw stances.

His first fight in this category was against Joshua Onyango, serving as the main event of a card titled "Final Decision" which was held in Arecibo, Puerto Rico.

In the fourth round, the referee decided to stop the contest when Onyango was unable to respond to a combination, awarding Quintana a technical knockout victory.

In a rough and rugged slug-fest, Quintana was eventually overwhelmed by the speed and power of the younger Berto and would go on to lose the fight by an 8th-round TKO.

On May 5, 2012, Quintana defeated Deandre Latimore by KO in the 6th round to win the NABO light middleweight title.

The Puerto Rican boxer announced his retirement after suffering a fourth-round TKO defeat to Keith Thurman (19–0, 18KOs) at the Citizens Business Bank Arena in Ontario, California on the 24th of that month.

Throughout his career he won 29 of 33 professional contests, only coming up short against fellow world champion fighters Miguel Cotto, Paul Williams, Andre Berto and Keith Thurman.