When Gomez died, he was named labor inspector for Zulia state, center of the oil industry, by the government of Eleazar López Contreras.
During his first nomination to Congress, he distinguished himself by defending the economic interests of his state at the time when imports from the USA were restricted because of World War II.
Together with politicians such as Alfredo Tarre Murzi and Arturo Uslar Pietri, he was one of the founders of the Venezuelan Democratic Party (Partido Democratico Venezolano, PDV), created to support the administration of president Isaias Medina Angarita.
[2] When this government was overthrown in the Revolution of October 1945, Ramírez MacGregor was briefly jailed by the junta, formed by Accion Democratica party (AD) and military officers, that ruled the country until 1948.
When democracy was restored to Venezuela in 1958, Ramírez MacGregor returned to politics, but finally resigned to active participation when he refused to back the candidacy of the AD leader Carlos Andrés Pérez.