Carmen de Santistevan y Avilés (May 3, 1810 – March 30, 1904) was the First Lady of Ecuador from 1856 to 1859 as the wife of President Francisco Robles.

Carmen de Santistevan y Avilés was born on May 3, 1810, in Daule, then part of the Spanish Empire.

[1][4] The marriage produced three children, the first of whom did not reach adulthood: Her son Ignacio became a corvette captain, the civil and military chief of the Plaza de Guayaquil (1895), Eloy Alfaro's Minister of Foreign Affairs (1895–1896), the governor of Guayas (1896–1898), and the consul of Mexico in Guayaquil (1896–1902), among other posts.

[2] A practicing Catholic, she joined others (such as First Lady Teresa Jado) in defending the cause of the Jesuits who unexpectedly arrived in Guayaquil when they were expelled from the Republic of New Granada in 1851.

[1] She was buried in the General Cemetery [es], where the family owned a mausoleum richly decorated with sculptures.