The church of the Carmine Maggiore is a Roman Catholic church located on Piazza Carmine in front of an open market in the city of Palermo, region of Sicily, Italy.

A church at this site appears to date to the 13th-century with the arrival of monks from the Carmelite order, who had left the Holy Land circa 1235.

Gothic tracery in one of the chapels likely derives from an earlier church.

Niches on the pilasters of the dome hold four statues by Vincenzo Messina: St Elias, John the Baptist, Jonah, and Moses.

The chapel of the Madonna del Carmine was stuccoed by Giacomo Serpotta.