Carolina la O made her live debut at the age of six, singing a traditional song called "Campesina Santandereana" at her elementary school.

In 2004, Carolina continued her success when asked to join a popular Latin American reality TV series, Telemundo's Protagonistas de la Fama VIP.

After ten years of developing solo careers, the three soneros from Alquimia, Carolina la O and the twins Jorge and Sady Ramirez, reunited.

With eclectic material ranging from songs once performed by Trio Matamoros, Celia Cruz, Oscar D’Leon, Héctor Lavoe, and even Marc Anthony, the album attempts to bring everything together with a cohesive group sound.

[15][16] Carolina la O received two Billboard Latin Music Award nominations[17] for Tropical Female Artist of the Year for her album Dulce Veneno in 2002.

In 2010, the Colombian singer remained a leader at or near the top of pop charts, ranking #5 in the U.S. overall, #1 in Puerto Rico, and #1 in Venezuela, Ecuador and Peru for "Qué Queda de Este Amor" and "El Último Beso," songs that also appear on her album Carolina la O En Vivo.

She returned to her native Colombia on the hospital ship Comfort as a member of the humanitarian mission an American squadron held in the town of Coveñas and surrounding communities in August of that same year.

She performed on board the ship for its crew of nearly 900, and in the main square of the town, both times accompanied by the U.S. Air Force Band and some of her group's original members, for over 5,000 attendees.